| abstract |
The invention discloses a new intermediate I for synthesizing anti-AIDS drug enhancer cobicistat, a synthesis method of the intermediate and a key intermediate (2R, 5R)-1 for synthesizing cobicistat from the intermediate , the method for 6-diphenyl-2,5-hexanediamine, because the chirality of intermediate I can be controlled by different chiral raw materials and reducing conditions, so after deprotection, different chirality 1 can be obtained. ,6-diphenyl-2,5-hexanediamine, wherein (2R,5R)-1,6-diphenyl-2,5-hexanediamine is a key intermediate for synthesizing cobicistat. The method has the advantages of easy availability of raw materials, short route, simple operation and low cost. |