http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109897091-B
Outgoing Links
Predicate | Object |
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classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 |
filingDate | 2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-109897091-B |
titleOfInvention | Cyclic antibacterial peptide containing unnatural amino acid and preparation method and application thereof |
abstract | The invention belongs to the technical field of antibacterial agents, and particularly relates to a cyclic antibacterial peptide containing unnatural amino acids, and a preparation method and application thereof. The amino acid sequence of the cyclic antibacterial peptide is shown as SEQ ID NO.1, the cyclic antibacterial peptide is an intramolecular cyclic polypeptide, and an intramolecular cyclic structure is formed by cyclization between the side chain of an unnatural amino acid Dap and a cysteine residue, wherein the sequence contains the unnatural amino acid Dap, proline of the polypeptide at a beta corner is replaced by proline of the polypeptide at the beta corner D PRO‑ L PRO to increase the stability of the beta-turn. The antibacterial peptide has the advantages of simple amino acid sequence structure, convenient synthesis and high antibacterial activity, and can be used for preventing and treating diseases caused by candida albicans. |
priorityDate | 2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.