http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109897027-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2019-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109897027-B |
| titleOfInvention | Synthesis method of 3-hydroxychloroloratadine metabolite |
| abstract | The invention discloses a synthetic method of 3-hydroxychloroloratadine metabolite, belongs to the field of drug metabolism, and provides a synthetic method which has reasonable process design, strong operability and high yield, can efficiently convert isotope-labeled raw materials into labeled target products, and can realize industrialized production of isotope-labeled 3-hydroxychloroloratadine metabolite. The deuterium 2-labeled formaldehyde is used as an initial raw material and is synthesized through six-step reaction, the optimal preparation steps and reaction conditions are screened out through a large number of experiments, the whole process is reasonable in design and strong in operability, the labeled raw material can be efficiently converted into a labeled target product, the chemical purity of the labeled 3-hydroxy desloratadine metabolite prepared by the method can reach more than 98.5%, and the abundance of the labeled isotope is more than 98.5%. |
| priorityDate | 2019-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.