| abstract |
The present invention provides a combination medicine comprising two, three or more than four independent compounds, wherein each compound is respectively a phosphodiesterase inhibitor, adenosine receptor antagonist, calcium channel blocker, histamine H1 -receptor agonist, histamine H2 -receptor agonist, histamine H3 - receptor antagonist or beta2-adrenoceptor agonist, or one or more of the active compounds thereof is isotopically enriched, isotopically enriched Set not less than 50%. The present invention also provides a combination medicament and method of use for the treatment, prevention or amelioration of cardiovascular disease in a subject comprising administering to a subject in need thereof a combination medicament of two, three or four separate compounds, wherein each The compounds are respectively phosphodiesterase inhibitor or adenosine receptor antagonist-theophylline or aminophylline, calcium channel blocker-nifedipine, histamine H1 - receptor agonist, histamine H2- Receptor agonists, histamine H3 - receptor antagonists-betahistine or beta2-adrenoceptor agonists-albuterol or lev-salbutamol. |