http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109879924-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_21c26629760d4cc6ae0ca44ce8315dd5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_066af93d226b9a8b1151cb1bc45bd190 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 |
| filingDate | 2017-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34c5456373aa88d9ed7126bbf8fc9dde http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e743c34244af780d7d67b74dfe740b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e7a940634466ba8fae9b60a8116c0f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edd4d4d84527221d7a08f1839f4481c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c65f1053a29c79f556dd441f7aabc542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e42599bb39fe90e7ec74fa4a0399a306 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8a63a2bdc6763184d494840269352b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_305f41c54380e7c73f20d56db3210bfa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff44025da472c93152119a8f0c23e464 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e8a74d5aae979f1d99ae45f952ce4e2 |
| publicationDate | 2019-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109879924-A |
| titleOfInvention | A kind of Austria's shellfish cholic acid purification process |
| abstract | Shellfish cholic acid (Obeticholic Acid, compound 1) difficult to understand is the native ligand of method Buddhist nun ester derivant X receptor (FXR), cholic acid can be inhibited to synthesize, for treating primary biliary cirrhosis and non-alcohol fatty liver.During preparation shellfish cholic acid difficult to understand, it was found that a kind of new unknown impuritie compound 2.Effect using traditional organic solvent recrystallization method removal impurity compound 2 is undesirable, and obtained shellfish cholic acid finished product purity difficult to understand is not also high.In order to overcome drawbacks described above, the present invention provides a kind of easy to operate, methods for being convenient for industrialized production preparation high-purity Austria shellfish cholic acid: converting difficulty soluble salt, acidification, recrystallization through saponification, soluble-salt for crude product Austria shellfish cholic acid, finally obtain high-purity Austria shellfish cholic acid product, wherein shellfish cholic acid purity >=99.0% difficult to understand, 2 content≤0.1% of compound. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113387992-A |
| priorityDate | 2017-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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