| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a712e6e7965beef77cd96f7cf92d3ca2 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-16 |
| filingDate |
2017-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac1f4537700d07911a2fa165022447b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d54e063b283c5a1e6d9c2a8744eab31e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95c84bfcf40765048bb20394aa16bdb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_add431d4ac31847aca730169aadf07f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_799f1d370945085992fa93f764f90208
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e204adfd79c8ec978f2add0479e28283
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_209e1b4ccdc909d393f499473a6df4fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2a0a814b84bae7c5f50ad7fd7a82abc |
| publicationDate |
2019-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109867734-A |
| titleOfInvention |
The cyclodextrine derivatives and preparation method thereof of a kind of caffeic acid modification |
| abstract |
The invention belongs to field of pharmaceutical chemistry research, and in particular to a kind of caffeic acid-amido-beta-cyclodextrin derivative (I) and preparation method thereof.The beta-cyclodextrin derivative (I) of the antioxidant caffeic acid modification has no document report.The present invention is with beta-cyclodextrin (β-CD) for raw material; it is reacted in a solvent in the presence of alkali with paratoluensulfonyl chloride; obtain mono- 6- deoxidation -6- p-toluenesulfonyl-beta-cyclodextrin (1); the product further reacts to obtain amine group-beta-cyclodextrin (2) with amine reagent, and compound (2) further reacts to obtain caffeic acid-amido-beta-cyclodextrin derivative (I) with caffeic acid；Caffeinic introducing assigns cyclodextrin certain antioxygenic property. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114478937-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114163817-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108948230-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108948230-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112111025-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113616813-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112111025-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113481658-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114163817-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114292367-A |
| priorityDate |
2017-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |