http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109867694-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-572 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572 |
| filingDate | 2019-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109867694-B |
| titleOfInvention | Synthesis method of oxygen-guided 7-alkynyl indole compound |
| abstract | The invention discloses a synthetic method of an oxygen-guided 7-alkynyl indole compound. The synthesis method comprises the following steps: in the reactor, di-tert-butyl (1) is added H The preparation method comprises the following steps of (1) stirring and reacting an-indole-1-yl) phosphine oxide compound, alkyne halide, a palladium salt catalyst, an oxidant, a ligand and a solvent at the temperature of 80-100 ℃, and separating and purifying reaction liquid to obtain the 7-alkynyl indole compound. The process of the present invention develops di-tert-butyl (1) H The cross coupling reaction of-indole-1-yl) phosphine oxide and alkyne halide constructs a series of highly functionalized 7-alkynyl indole compounds, and has extremely high step economy and atom economy. In addition, the main characteristics of the reaction are simple and easily available raw materials, safe operation, good regioselectivity and wide substrate universality. |
| priorityDate | 2019-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.