http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109867676-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 |
| filingDate | 2017-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109867676-B |
| titleOfInvention | Pyrrolopyrimidine derivative compound, pharmaceutical composition and application thereof |
| abstract | The invention provides a pyrrolopyrimidine derivative compound shown as a general formula (I) or a pharmaceutically acceptable salt, solvate, active metabolite, polymorph, isotopic marker, isomer or prodrug thereof. The invention also provides a pharmaceutical composition containing the same and application of the compound and the pharmaceutical composition in preparing medicines for treating JAK kinase mediated diseases. The pyrrolopyrimidine derivative compound and the pharmaceutical composition thereof provided by the invention have obvious JAK kinase inhibition activity and excellent pharmacokinetic properties, especially have high-selectivity JAK1 enzyme inhibition activity, and can avoid potential side effects caused by inhibition of other JAK kinases while ensuring the excellent inhibition effect of JAK1 enzyme, so that the pyrrolopyrimidine derivative compound and the pharmaceutical composition thereof have very high application potential. |
| priorityDate | 2017-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 131.