| abstract |
The invention relates to the field of medicinal chemistry, in particular to a class of PARP and PI3K dual targets containing 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine and phthalazine-1(2H)-one structures Inhibitors (I) and their preparation methods, and pharmacodynamic tests prove that the compounds of the present invention have PARP and PI3K dual-target inhibitory activity, and can be used for anti-tumor. |