| abstract |
The present invention provides polymyxin-alginate oligomer conjugates comprising polymyxins covalently linked to at least one alginate oligomer via direct covalent bonds or covalent molecular linkers An antibiotic, or a pharmaceutically acceptable salt, solvate, hydrate, diastereomer, tautomer, enantiomer or active metabolite thereof. Also provided are methods of making the conjugates, pharmaceutical compositions comprising the conjugates and methods of treating or preventing a bacterial infection in a subject having, suspected of having, or at risk of having a bacterial infection the use of. |