http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109837326-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6825 |
| filingDate | 2019-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109837326-B |
| titleOfInvention | Detection method of biological target molecules based on multivalent capture and amplification of output signal |
| abstract | The invention discloses a biological target molecule detection method based on multivalent capture and amplification of output signals, belonging to the technical field of biological detection. The detection method includes: adding a recognition probe to the solution to be tested, recognizing and binding the target biological target molecule and releasing the trigger sequence, triggering the sequence to open the clip probe to generate a hybridization chain reaction, then adding an auxiliary probe, blocking the non-participant The reaction hairpin probe, then the carrier with the capture probe self-assembled on the gold interface is placed in the reaction solution, the hybridization chain reaction product is captured on the gold sheet, and finally the change of the signal label on the gold interface is analyzed, and then the waiting time is calculated. Measure the content of target biological target molecules in the sample. The invention forms multi-branched hybridization chain reaction products through hybridization chain reaction, and then uses interface multivalent capture to amplify and output signals, thereby realizing the detection of target molecules; with the help of auxiliary probes, the hybridization chain reaction of sensing interface capture is improved. Product efficiency and improved detection sensitivity. |
| priorityDate | 2019-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.