http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109833329-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-61 |
| filingDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109833329-B |
| titleOfInvention | Hyaluronic acid-porous nano selenium compound and preparation method and application thereof |
| abstract | The invention belongs to the technical field of nano materials, and discloses a hyaluronic acid-porous nano selenium compound and a preparation method and application thereof. Specifically, the porous nano-selenium aqueous solution is mixed with EDC and NHS for activation, and then the activated porous nano-selenium aqueous solution is mixed with HA for reaction to obtain the hyaluronic acid-porous nano-selenium compound aqueous solution. The nano selenium with the super-large specific surface area and the porous structure can eliminate active oxygen to inhibit inflammation and oxidation damage, has higher affinity and reactivity to the active oxygen compared with the traditional nano selenium, and enhances the electron affinity and conduction efficiency of the active oxygen and the nano selenium. And through the modification of HA, the targeting property of the porous selenium to inflammatory macrophages is improved, and the drug intake of cells can be increased, so that the intracellular drug is maintained at a higher level. Enhances the activity of the porous selenium for eliminating active oxygen in inflammatory cells and in vivo, and provides a thought for the functional modification of selenium antioxidants. |
| priorityDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.