http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109825538-B
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02E50-10 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00 |
filingDate | 2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2022-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2022-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-109825538-B |
titleOfInvention | Synthesis method of chiral 2-amino-1-butanol |
abstract | The invention discloses a method for synthesizing chiral 2-amino-1-butanol. The method comprises the following steps: using 1, 2-butanediol as a substrate, and generating 2-ketone-1-butanol through catalytic reaction of enzyme A and coenzyme thereof; 2-keto-1-butanol is used as a substrate, and chiral 2-amino-1-butanol is generated through catalytic reaction of enzyme B and coenzyme thereof; the enzyme A is selected from alcohol dehydrogenase, carbonyl reductase or a mutant of the two enzymes; the enzyme B is selected from amino acid dehydrogenase, transaminase or mutants of both enzymes. The invention provides a brand-new green biosynthesis route, which takes cheap 1, 2-butanediol as a raw material to synthesize chiral 2-amino-1-butanol, namely (S) -2-amino-1-butanol and (R) -2-amino-1-butanol, through multi-enzyme co-expression or cascade or step-by-step catalysis. |
priorityDate | 2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 244.