http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109824871-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G61-12 |
| filingDate | 2019-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109824871-B |
| titleOfInvention | Near-infrared two-zone fluorescent quinoid polymer, preparation method and application thereof |
| abstract | The invention discloses a preparation method and application of a quinoid polymer near-infrared two-region imaging contrast agent, belonging to the technical field of nano biomedical imaging. The invention firstly uses 2-formic acid dodecyl ester-thieno (3,4- b ) Thiophene is taken as a quinoid structural unit and is respectively subjected to suzuki coupling reaction with three donor units with different lengths, namely thiophene, bithiophene and trithiophene, so as to obtain the near-infrared two-zone fluorescent polymer with the quinoid structure. The quinoid polymer can conveniently control and enhance the fluorescence intensity of a near-infrared two-region by controlling the density of a 2-dodecyl formate ester group with a side chain capable of absorbing electrons. And then the near-infrared two-region fluorescent polymer and the amphiphilic block polymer F-127 are self-assembled, so that the obtained water-soluble nano particles have good fluorescence brightness in the near-infrared two regions, can be used as a contrast agent to realize cell tracking imaging in the near-infrared two regions, and can accurately guide surgical excision of transplanted tumors. |
| priorityDate | 2019-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.