http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109824801-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G83-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C03C17-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-16 |
| filingDate | 2019-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109824801-B |
| titleOfInvention | Synthesis method of cyclodextrin modified dopamine derivative |
| abstract | The invention discloses a synthesis method of a cyclodextrin modified dopamine derivative, which comprises the steps of mixing mono-6-p-toluenesulfonyl cyclodextrin with dopamine hydrochloride according to a molar ratio of 1: 5-10, adding 4-dimethylaminopyridine and potassium iodide as catalysts, and vacuumizing to enable a reaction system to reach an anhydrous and anaerobic state; and respectively adding anhydrous N, N-dimethylformamide and anhydrous methanol, stirring, dissolving a solid sample, adjusting the pH value to weak acidity, reacting at 80-100 ℃ for 12-24 hours to obtain a reaction mixed solution, performing rotary evaporation to volatilize the solvent, and performing column chromatography elution to obtain the mono-6-deoxy-dopamine cyclodextrin derivative. The cyclodextrin modified dopamine derivative synthesized by the invention reduces the problem of uneven settlement of polydopamine on the surface of the material, has excellent performance of realizing degradability in a living body, and overcomes the defects that an oil-soluble drug material is difficult to combine with hydrophilic polydopamine and the fixation and sustained release of the drug are difficult to realize. |
| priorityDate | 2019-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.