http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109824601-B

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-10
filingDate 2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-109824601-B
titleOfInvention Method for synthesizing chiral cyclic urea through asymmetric hydrogenation of iridium-catalyzed 2-hydroxypyrimidine compound
abstract The invention provides a chiral ring synthesized by asymmetric hydrogenation of an iridium-catalyzed 2-hydroxypyrimidine compoundA process for the preparation of urea-like compounds, in the formula: r is C1-C6 alkyl or aryl; r' is aryl, heteroaryl or alkyl containing substituent groups, wherein the substituent groups are F, Cl and CF 3 Me and MeO. The synthesized chiral cyclic urea has an enantiomeric excess of 96%. The method has the advantages of simple, convenient, practical and feasible operation, high yield, environment friendliness, commercial availability of the catalyst, mild reaction conditions and potential practical application value.
priorityDate 2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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