http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109810093-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ecda51df432101d6989a3c81fa399da0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2017-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20eef2fa44530043e63fd69b8eca04d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c98b98c0629623ed53ef42ab729ae421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_998c34ecaace153dcd1005501ff1170f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb31915b620ea067390fcc056b9317e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_127040ac774dec0d40fb4ef1faf6e8da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a01de8b46509885dcd1dd72f030d582 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e65e88e3dfe11a27c0cd4997263e97e7 |
| publicationDate | 2019-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109810093-A |
| titleOfInvention | A kind of preparation method of bilastine intermediate |
| abstract | The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of a bilastine intermediate, which is named 1-piperidinecarboxylic acid, 4-[1-(2-ethoxyethyl)-1H-benzimidazole -2-yl]-,1,1-dimethylethyl ester. The above-mentioned intermediate compound is generated by 2-(4-piperidine)-1H-benzimidazole after being protected by di-tert-butyl dicarbonate, and further reacted with 2-ethoxychloroethane. The above product is deprotected under acidic conditions and undergoes a substitution reaction to generate 1-(2-ethoxy-ethyl)-2-piperidine-4-yl-1H-benzimidazole. The preparation method of the new intermediate of bilastine provided by the invention provides a new way for the synthesis of bilastine. Purity, suitable for industrial scale production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112110892-A |
| priorityDate | 2017-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.