http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109810048-A

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c91edfc7f31b9995a01e240617643f2f
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-66
filingDate 2017-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84b1c9a0e103b5e6cb39a9697d1de743
publicationDate 2019-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-109810048-A
titleOfInvention A kind of new synthetic method of Carfentanil
abstract The invention belongs to organic synthesis fields, and in particular to a kind of synthetic method of Carfentanil synthesis.The synthetic method is using N-Boc protecting group piperidones as raw material, and by Bargellini reaction, N- is acylated, methylation, be deprotected, N- is alkylated 5 steps and has obtained target product Carfentanil.The present invention uses Carfentanil new synthetic method, avoids the use of extremely toxic substance potassium cyanide, and environmental-friendly, yield is higher, and synthetic route is relatively easy, can satisfy the requirement of Modern high throughput, inexpensive synthesis theory.
priorityDate 2017-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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