http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109810013-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c91edfc7f31b9995a01e240617643f2f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-84 |
| filingDate | 2017-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84b1c9a0e103b5e6cb39a9697d1de743 |
| publicationDate | 2019-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109810013-A |
| titleOfInvention | A kind of preparation method of Rhein-amino acid conjugate |
| abstract | The invention belongs to organic compound synthesis technical fields, and in particular to a kind of preparation method of Rhein-amino acid conjugate.Preparation method of the present invention, Rhein methyl esters 1-2g is weighed in parts by weight to be put into reaction vessel, DMAP 35-45 ml is added again, highly basic sodium hydride 0.3-0.8g and halogenated hydrocarbons 1-3g, 100-120 DEG C of reaction temperature, reaction time 10-25min, the hydrochloric acid solution of 40-60 ml is added again, isothermal reaction 5-10min, it is extracted with dichloromethane after reaction, product extracted is added in 35-38ml sodium hydroxide solution, reaction temperature is 50-60 DEG C, reaction time 15-30min, high-speed stirred, adjusting pH again is faintly acid, amino-acid ester 1-3g is added again, reaction 5-15min is stirred at room temperature, the hydrochloric acid solution of 40-60ml is added again, isothermal reaction 5-10m In is extracted with dichloromethane 2-4 times after reaction, is precipitated and filters to solid, and anhydrous sodium sulfate is drying to obtain finished product.Preparation method of the present invention has many advantages, such as that soluble, bioavilability is high, process equipment requirement condition is low, processing step is simple, and synthetic ratio is high. |
| priorityDate | 2017-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.