http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109796436-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_820fbfb47c3eeadbf3b71a28e70e174c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2019-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf31f697ec15cd0c552cca518d8cda98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe30c13ac13397ec0e828d9473d7cf21 |
| publicationDate | 2019-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109796436-A |
| titleOfInvention | A kind of method of the trans- 4 '-carboxyl cotinine of high-purity (±)- |
| abstract | The invention discloses a kind of high-purity (±)-trans- 4'- carboxyl cotinine synthetic methods, which is characterized in that reacts the ethanol solution of methylamine with 3- pyridine carboxaldehyde, 25~30 DEG C of temperature of control, maturation is reacted, solvent is then concentrated under reduced pressure, obtains alkene imine intermediate I；Alkene imine intermediate I is added in dimethylbenzene, succinic anhydride is added, then the maturation that flows back；Reaction solution is cooled to room temperature, removal dimethylbenzene is then concentrated under reduced pressure；After concentration, the pH value of concentrate is adjusted to 8~9, organic impurities is extracted with dichloromethane again, organic phase is removed after layering, white solid is obtained, is successively washed after suction filtration, cold ethanol rinse, vacuum drying obtains purpose object crude product, it is recrystallized with ethyl alcohol to get high-purity (±)-trans- 4'- carboxyl cotinine.High-purity (±) produced by the present invention-trans- 4'- carboxyl cotinine HPLC purity can reach 99% or more, 60% or more total recovery. |
| priorityDate | 2019-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.