http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109796412-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2019-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109796412-B |
| titleOfInvention | 5- (tetra-substituted alkenyl) -3, 5-dihydro-4H-imidazole-3-ketone derivative and synthesis method and application thereof |
| abstract | The invention relates to a 5- (tetra-substituted alkenyl) -3, 5-dihydro-4H-imidazole-3-ketone derivative, a synthetic method and application thereof. The invention takes a compound with an N- (isoxazole-3-yl) -alkynylamide or an N- (1, 2, 4-oxadiazol-3-yl) alkynylamide structure as a raw material, reacts with a nucleophilic reagent under an alkaline condition, and directly generates the 5- (tetra-substituted alkenyl) -3, 5-dihydro-4H-imidazole-3-one derivative through Michael addition reaction of the nucleophilic reagent to the alkynylamide and Boulton-Katritzky rearrangement reaction. The method has wide substrate applicability, simple and efficient preparation method and good functional group compatibility. The 5- (tetra-substituted alkenyl) -3, 5-dihydro-4H-imidazole-3-ketone derivative synthesized by the invention has anti-tumor activity and wide application prospect. |
| priorityDate | 2019-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.