http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109796408-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-20 |
| filingDate | 2019-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109796408-B |
| titleOfInvention | Synthetic method of 5-difluoromethoxy-3-trifluoromethyl-1-methylpyrazole |
| abstract | The invention relates to the field of organic synthesis, in particular to a method for synthesizing 5-difluoromethoxy-3-trifluoromethyl-1-methylpyrazole, which comprises the following steps: reacting 1-methylpyrazole with a halogenating agent under the action of a metal reagent to generate 5-halo-1-methylpyrazole; reacting 5-halogeno-1-methylpyrazole with difluoromethanol under the catalysis of alkali to obtain 1-methyl-5-difluoromethoxypyrazole; the 1-methyl-5-difluoromethoxy pyrazole reacts with a trifluoromethyl reagent under the action of visible light catalysis and a photocatalyst to obtain the 5-difluoromethoxy-3-trifluoromethyl-1-methylpyrazole. The invention has the beneficial effects that through redesigning the route, 5-difluoromethoxy-3-trifluoromethyl-1-methylpyrazole can be obtained with high yield and high selectivity by using cheaper and easily obtained raw materials with low toxicity. |
| priorityDate | 2019-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.