abstract |
The present invention relates to biomedicine technical fields, the present invention selects the analysis that microRNAs express spectra is carried out in Multiple Myeloma slurry, and utilize qPCR technical identification, relative in normal health crowd, the expression of miR-145-3p is significantly reduced in Multiple Myeloma slurry.The present invention observes the level of Apoptosis and autophagy further through miR-145-3p overexpression, miR-145-3p silencing, as a result, it has been found that, miR-145-3p can promote Apoptosis and autophagy.The present invention provides new serology marker for diagnosis Huppert's disease disease;Also new target spot is provided for the prevention and treatment of Huppert's disease disease. |