| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_872dd7cd609eb2a937dcfd303d521798 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate |
2017-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe6455892e2ff87c35ddfbffe522d0a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de89badcca2ac09870b0828c4d015bd4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce409a7558cef66740826595f00daec4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6a51614c77f85d3e36750e393332551
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_064130899e37864a8af5f2146968ddcc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_add3d421ec680a89fed5b2990f3428ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_841e072428290ed482928a6217551551 |
| publicationDate |
2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109790216-A |
| titleOfInvention |
Antibodies with reduced binding to process impurities |
| abstract |
The present invention relates to variant antibodies and methods of producing such antibodies with reduced levels of binding to process impurities. In particular, the present invention describes variant IgG4 antibodies that have been modified at any one or combination of amino acids in the region between Kabat residues 203 and 256 in the heavy chain constant region, wherein the variant IgG4 antibodies The antibodies have reduced levels of binding to host cell proteins (HCPs) compared to unmodified IgG4 antibodies. The present invention also relates to compositions comprising said variant IgG4 antibodies. |
| priorityDate |
2016-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |