| abstract |
The present disclosure relates to multivalent pneumococcal vaccine compositions comprising serotypes of capsular pneumococcal polysaccharide individually conjugated to a carrier protein, respectively. When conjugated, the combination of a pneumococcal capsularis polysaccharide serotype and a carrier protein is referred to herein as a polysaccharide-protein conjugate. The pneumococcal vaccine composition may also comprise one or more of the following; pharmaceutically acceptable carriers, pharmaceutically acceptable diluents, buffers, preservatives, stabilizers, adjuvants and/or lyophilization excipient. Also provided are methods of making and administering the pneumococcal vaccine compositions described herein. |