http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109776543-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_157f6ea8a2b996328769d9b5e934655f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcaa03b795cd8da869d58e8f28bf52e5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2017-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6765936b94749a4e7c5c1ec15ff94fac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1278857aaadd78ad0fc917b84d9fd08a |
| publicationDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109776543-A |
| titleOfInvention | Ibrutinib salt, its crystal, preparation method, pharmaceutical composition and application |
| abstract | The invention discloses ibrutinib salt, its crystal, preparation method, pharmaceutical composition and application. The crystal of the ibrutinib salt has the structure shown in formula (I), wherein X is HCl, HBr or benzoic acid. The preparation method includes the following steps: in an organic solvent, ibrutinib and X are mixed, heated to a temperature of 40-130° C., completely dissolved, and cooled for crystallization. The crystals of the three salts of ibrutinib disclosed in the present invention are all new crystal forms, have excellent solubility, thermal stability, and greatly improved hygroscopicity, greatly improving the solubility and biological properties of ibrutinib Utilization, and the preparation method of the crystal is simple, suitable for large-scale industrial production, and has a good industrial application prospect. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106995445-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106995445-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110317203-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110317203-B |
| priorityDate | 2017-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.