http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109776407-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14 |
| filingDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109776407-B |
| titleOfInvention | Preparation method of 2-methyl-4-hydroxymethyl quinoline and derivatives thereof |
| abstract | The invention belongs to the technical field of chemical synthesis, and particularly relates to a method for reacting 2-methylquinoline and derivatives thereof with primary alcohol. The method is realized by the following steps: in the Selectfluor/AgNO 3 Under the catalysis, 2-methylquinoline and derivatives thereof react in primary alcohol aqueous solution, and a 4-position of the 2-methylquinoline derivative and a product of dehydrogenation coupling of an alcohol compound are obtained after column chromatography. The method provided by the invention is carried out on Selectfluor/AgNO 3 The method is carried out in a mixed solution of water and alcohol compounds under catalysis, and has good substrate solubility and wide applicability; high reaction yield and strong controllability. The method provided by the invention is green and environment-friendly, has few side reaction products, and is green and efficient. |
| priorityDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.