http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109762896-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f68ddaa0ddd894016af217422d657c22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 |
| filingDate | 2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9620b852fee435a78a7b215244b5b8a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4603f1aa5160f56e508b19707537a12f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_854fd95ee28ca060f46a310f161a2fde http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_467019a71d3a48f526019e909895301e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_051dbf3746dd441a47b73e5aa6fdeb7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91e99021ad9bd64b7d356dd264535722 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f3e8cca69bed2852e70be20e6cc44ac |
| publicationDate | 2019-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109762896-A |
| titleOfInvention | A marker of multiple sclerosis MiR-125a-5p |
| abstract | The invention belongs to the technical field of medicine and discloses a marker MiR-125a-5p of multiple sclerosis and a kit for detecting multiple sclerosis. The present invention finds that in the autoimmune encephalomyelitis mouse model, the expression of VDR in the anterior horn of the lumbar spinal cord is decreased, and the expression of miR-125a-5p is significantly increased. After intrathecal injection of a miR-125a-5p inhibitor, experimental autoimmune The expression of vitamin D receptor was also significantly increased in mice with encephalomyelitis, the clinical score was decreased and the body weight was significantly increased, and the clinical symptoms were significantly relieved, and the miR‑125a‑5p inhibitor had a good therapeutic effect. Confirmation of the pivotal role of miR‑125a‑5p as a marker of multiple sclerosis in regulating vitamin D receptor biology in experimental autoimmune encephalomyelitis as a potential new therapeutic intervention, diagnostic marker and therapeutic targets. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111378742-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114196748-A |
| priorityDate | 2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.