http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109762170-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G79-04 |
| filingDate | 2019-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109762170-B |
| titleOfInvention | Polyphosphate polymer and preparation method thereof, modified porous silicon nanoparticles and preparation method and application thereof |
| abstract | The invention relates to the technical field of pharmaceutical preparations, in particular to a polyphosphate polymer and a preparation method thereof, and modified porous silicon nanoparticles and a preparation method and application thereof. The main chain of the polyphosphate ester polymer provided by the invention is a polyphosphate ester chain segment, the side chain is a zwitterionic chain segment, and the polyphosphate ester polymer has good biocompatibility and degradability, can obviously increase the colloid stability of the nanoparticles by introducing the polyphosphate ester chain segment to the surface of the porous silicon nanoparticles, can penetrate through mucus more quickly, reduces the retention amount of the nanoparticles in a mucus layer, has better affinity to epithelial cells, greatly improves the endocytosis amount of the cells, can effectively release medicine inside and outside the cells in a cross-cell manner, and is favorable for improving the bioavailability of the medicine. Meanwhile, in the polyphosphate ester polymer provided by the invention, active sites of a polyphosphate ester chain segment are easy to couple with a targeting factor, and the affinity of a hydrophilic polyphosphate ester chain segment and a cell membrane is high, so that the safety of the nanoparticle can be effectively improved compared with the existing nanoparticle for promoting mucus diffusion. |
| priorityDate | 2019-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 184.