http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109761838-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_066af93d226b9a8b1151cb1bc45bd190 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_79316eeaf1bb028331ec423337beb09a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 |
| filingDate | 2019-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23a298fc159e2a1daaac662cf241e7ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4167643cf54f87fa70e28db643a164ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97952c62f6dbb7997d388b59fbed7c64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53437b1a512712df91347a59d5571dc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7927f9d02cb1a17d69a61029c19bb8e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_537b2da06263323f2d499a5b57b67031 |
| publicationDate | 2019-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109761838-A |
| titleOfInvention | A method of preparing pregabalin intermediate and recycling resolving agent |
| abstract | The invention discloses a kind of methods for preparing pregabalin intermediate (R) -3- isobutylglutaric acid monoamides and recycling resolving agent (R)-phenyl ethylamine, method includes the following steps: 1) compound 7 is dissolved in the water；2) Ionic Membrane is added, adjusts pH to 11.0~13.0；3) hydrochloric acid is added, adjusts pH to weakly acidic pH；4) organic solvent extracting and demixing is added；5) hydrochloric acid is added in water layer in step 3), adjusts pH to 1.0~3.0；6) 0~15 DEG C of crystallization, rejection filter, drying are cooled to and obtains (R) -3- isobutylglutaric acid monoamides；7) with after middle boiling, 90~130 DEG C of fractions of collection are recycled (R)-phenyl ethylamine for boiling before organic layer is evaporated under reduced pressure out in step 4).The present invention is under current safety and environmental protection, upgrading synergy and market keen competition form, with obvious advantage, the present invention is to provide a safety and environmental protections, simple and convenient, high income the method for preparing pregabalin intermediate (R) -3- isobutylglutaric acid monoamides and recycling resolving agent (R)-phenyl ethylamine. |
| priorityDate | 2019-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.