http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109761828-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_31f7f4d0fc807c98c145cd77018bf2eb |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-36 |
| filingDate | 2019-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6591ac0b3fdf51008bb81099f7cd7e5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a04a467e82ce11918fe4ce8ccf8179ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bebea089bdeef54fe5a640cdd86de034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d50be711da41697b2ade6969ac3345b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10c42c598230dff8a0e641b34741a01c |
| publicationDate | 2019-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109761828-A |
| titleOfInvention | A kind of preparation method of salbutamol sulfate intermediate |
| abstract | Salbutamol is a beta receptor agonist. At present, the preparation process of salbutamol is mainly based on the original research process. The original research process uses p-hydroxyacetophenone as the starting material, and undergoes chloromethylation, esterification, bromination, amine The salbutamol is prepared by synthesizing, hydrolyzing and reducing. The existing synthetic method of the salbutamol sulfate intermediate is synthesized in multiple steps, the operation is complicated, the product loss is large in the preparation process, and the process time is long. The preparation method of the salbutamol sulfate intermediate of the present invention is as follows: compound I reduces carbonyl group under the action of a reducing agent to obtain compound II, and then adds a debenzylation reagent to carry out debenzylation reaction to obtain the salbutamol sulfate intermediate III. The invention adopts "one-pot method" to directly prepare salbutamol sulfate intermediate III from compound I, reduces operation steps, shortens reaction time and improves reaction yield. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112062684-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112062684-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115057788-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112979480-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112745292-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116283619-A |
| priorityDate | 2019-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.