http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109758589-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2019-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109758589-B |
| titleOfInvention | Flexible up-conversion blue light sensor capable of in vivo regulation of allosteric cryptochrome CRY2 protein and preparation method thereof |
| abstract | The invention discloses a flexible up-conversion blue light sensor capable of in vivo regulation of cryptochrome CRY2 protein allostery and a preparation method thereof, comprising the following steps: 1) preparation and characterization of blue-light emission up-conversion micro-rods doped with rare earth thulium element; 2 ) Preparation of flexible up-conversion blue light sensor: (1) Polydimethylsiloxane precursors in different ratios of 10:1 to 7:1 were prepared, and mixed with blue-light emission upconversion microrods doped with rare earth thulium at 10 mg/ml ～100mg/ml, negative pressure 0.03MPa～0.05MPa, vacuumize for 30min～40min to remove air bubbles, spin-coat the mixture evenly on the polyester film; (2) After the liquid is formed into a film of 0.2mm～3mm, cure at 80℃ for 30min in vacuum and high temperature ~60min; (3) After cooling, press tightly to avoid bubbles. The sensor of the invention has an area of 25 mm 2 to 1 cm 2 , and can emit bright blue light with a wavelength of 470 nm under the excitation of 980 nm near-infrared light, and the blue light emitted by the sensor can change the structure of the cryptochrome CRY2 protein and realize the safety of the up-conversion particles in the living body. Efficient light conversion. |
| priorityDate | 2019-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.