http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109750067-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a42d2f4bf87ee52614c7b4cdb91afe5 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-93 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate | 2017-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfaf893c4fdabe65ac225bfdf056ddb0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce8230c28af4e09fac5bb600124b6c2a |
| publicationDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109750067-A |
| titleOfInvention | Cells co-expressing secreted anti-immune checkpoint antibodies and tEGFR molecules and their applications |
| abstract | The present invention provides an expression vector, a lentivirus, a transgenic cell, a secreted antibody and a therapeutic composition for treating cancer. The expression vector carries the following nucleic acid molecules: a first nucleic acid molecule encoding a fragment of a secretory immune checkpoint inhibitor molecule; optionally, a second nucleic acid molecule encoding a non-functional EGFR . The expression vector of the embodiment of the present invention is introduced into the recipient cells, and the secretory anti-immune checkpoint antibody is highly expressed in the recipient cells and secreted outside the cells, and the immune escape mechanism mediated by the immune checkpoint is inhibited. The expression vector of the embodiment of the present invention is introduced into recipient cells, such as lymphocytes, and the specific killing of lymphocytes to tumor cells is strong and effective. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022115635-A1 |
| priorityDate | 2017-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.