http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109745562-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 |
| filingDate | 2018-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109745562-B |
| titleOfInvention | Application of ERK signal channel small molecule inhibitor in inhibiting chlamydia infection |
| abstract | The invention discloses application of small molecule inhibitors VX-11e and BVD-523 in inhibiting chlamydia infection. The research of the invention finds that signal pathway inhibitors VX-11e and BVD-523 can obviously inhibit the infection of Chlamydia trachomatis, and compared with the reported MEK inhibitor U0126, the signal pathway inhibitors have obvious difference; the invention applies the micromolecule inhibitors VX-11e and BVD-523 to the chlamydia infection for the first time, and is expected to become a new drug for treating the chlamydia targeted host; meanwhile, the research also finds that the inhibitors VX-11e and BVD-523 have synergistic effect when being combined with azithromycin, and the VX-11e and BVD-523 can promote the anti-infection effect of the azithromycin after chlamydia infection, thereby having important application value for treating chlamydia infection. The invention has important significance for developing new medicaments for chlamydia trachomatis infection and searching new targets for assisting host treatment. |
| priorityDate | 2018-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.