http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109738495-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-327 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-26 |
| filingDate | 2019-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109738495-B |
| titleOfInvention | Tri-metal signal amplification aptamer sensor based on cerium metal organic framework @ gold nanocomposite and gold platinum ruthenium nanocomposite for detecting thrombin-sensitive protein-1 |
| abstract | The invention uses an aptamer as a target capture agent, and successfully develops a sensor for sensitive detection of thrombin sensitive protein-1 (TSP-1) based on a signal amplification strategy of a cerium metal organic framework @ gold nanocomposite (Ce-MOF @ Au) and a gold platinum ruthenium nanocomposite (AuPtRu NP). The synthesized AuPtRu NP can be used as a catalyst for catalyzing hydrogen peroxide, and can also be used as a nano carrier for capturing amino (-NH2) to terminate single-stranded DNA (S1) so as to obtain a signal probe SP (AuPtRu NP/S1). The Ce-MOF @ Au is obtained by in-situ reduction and is used as an electrode modification material of a glassy carbon electrode. When the detection solution contains H 2 O 2 The AuPtRu NP can oxidize H 2 O 2 To obtain an enhanced signal. The present invention shows from 1fg mL ‑1 To 10ng mL ‑1 Has a linear range of 0.13fg mL ‑1 Very low detection limit. In addition, the aptamer sensor can be directly used for detecting clinical practical samples. |
| priorityDate | 2019-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.