http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109734616-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-08 |
| filingDate | 2019-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109734616-B |
| titleOfInvention | Two-step method for synthesizing (Z)-3-amino-2-(2-fluoro-3-methoxyphenyl)-2-butenoic acid ethyl ester |
| abstract | The invention discloses a method for synthesizing (Z)-3-amino-2-(2-fluoro-3-methoxyphenyl)-2-butenoic acid ethyl ester by a two-step method, comprising the following steps: (1) 2-fluoro-1-iodo-3-methoxybenzene as shown in formula (II) and ethyl acetoacetate through coupling reaction to obtain (Z)-2-(2- as shown in formula (III) Fluoro-3-methoxyphenyl)-2-ethyl crotonate; (2) (Z)-2-(2-fluoro-3-methoxyphenyl)-2-ethyl butenoate shown in formula (III) is obtained as shown in formula (I) through amination reaction (Z)-3-amino-2-(2-fluoro-3-methoxyphenyl)-2-butenoate ethyl ester shown; The advantage of the present invention is that the target product can be obtained through two-step reaction by using the commercialized basic chemical raw material 2-fluoro-1-iodine-3-methoxybenzene as the starting material, which simplifies the synthesis route of the target product, It has the advantages of simple purification, high efficiency, high yield and low cost, and is suitable for industrial mass production. |
| priorityDate | 2019-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.