http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109731106-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y30-00 |
| filingDate | 2019-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109731106-B |
| titleOfInvention | Preparation method of compound for treating brain glioma |
| abstract | The invention relates to a preparation method of a compound for treating brain glioma, which comprises the following steps: firstly, heparin is used as a carrier to carry cRGD tumor targeting peptide, and is connected with adriamycin through a chemical acid-sensitive hydrazone bond to prepare the adriamycin nano-drug; and then under the catalysis of EDC/NHS, coupling carboxyl on the adriamycin nano-drug and amino on the surface of an exosome together, so that the nano-particles of the adriamycin nano-drug are densely distributed on the surface of the exosome vesicle. The compound for treating brain glioma prepared by the method can not only target tumors and pass through a blood brain barrier, but also has the advantage of high drug-loading rate. |
| priorityDate | 2019-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.