http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109722413-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077 |
| filingDate | 2019-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109722413-B |
| titleOfInvention | An osteogenic inducer and its application in the osteogenic induction and differentiation of adipose-derived mesenchymal stem cells |
| abstract | The invention discloses an osteogenic inducer and its application in the osteogenic induction and differentiation of adipose mesenchymal stem cells. RUNX2 is a key regulator in the process of osteogenic differentiation and can regulate the transcription of many genes. RUNX2 deletion can completely inhibit the differentiation of osteoblasts. It is found in the present invention that Angelica sinensis can significantly increase the expression level of RUNX2, an osteogenic differentiation regulator of adipose-derived mesenchymal stem cells, and is an effective RUNX2 expression activator; It was found that Angelicae can significantly increase the degree of calcium mineralization nodules in cells, indicating that Angelica has a significant induction effect on the osteogenic differentiation of ADSCs. |
| priorityDate | 2019-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.