http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109721657-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-10 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K101-02 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
filingDate | 2017-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-109721657-B |
titleOfInvention | Fusion protein for blocking PD-1/PD-L1 signal transduction pathway and activating T cells and application thereof |
abstract | The present invention provides a fusion protein that blocks the PD-1/PD-L1 signaling pathway and activates T cells, comprising (i) an antigen-binding fragment derived from an anti-PD-1 antibody and/or an anti-PD-L1 antibody; (ii) an immunoglobulin Fc domain; and (iii) CD80 extracellular domain (ECD). The invention also provides a polynucleotide encoding the fusion protein, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, and use of the fusion protein in treating, preventing and/or diagnosing diseases related to activation of PD-1/PD-L1 signaling pathway and inhibition of T cell function in an individual. |
priorityDate | 2017-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 840.