| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a483df1d4b5ea677dd937c512c750f2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 |
| filingDate |
2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abf834df5b160a88cdd194e44ba25811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0f6a87c530124782848097b41f28048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_753316722e6393612248aa61bdff2f14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c852014cd280f522ac338d599e5c4b8a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7f46e37d238bb21d8fb7f2c3b93de4f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0c8dc8b4dc8321b0f72e719053e9372
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21206fb628e76902b3c3d33cf0f457f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b89ebea38e3a62c1616d47e3db6b26d3 |
| publicationDate |
2019-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109721653-A |
| titleOfInvention |
A kind of glucagon-like peptide-1 fragment analog and application thereof |
| abstract |
The present invention discloses a glucagon-like peptide-1 fragment analog with weight loss and hypoglycemic activity, or a pharmaceutically acceptable salt thereof, the sequence of which is shown in the following general formula (I). The invention adopts microwave-promoted Fmoc/tBu orthogonal protection solid-phase synthesis strategy to efficiently and quickly synthesize the above target compound. The prepared GLP-1 fragment analog has a novel structure and is suitable as an active ingredient of a drug for treating diabetes and obesity. The GLP-1 fragment analog prepared by the microwave-promoted solid-phase synthesis technology provided by the present invention has the advantages of high yield, short synthesis period, easy crude product purification, low production cost and easy industrial automation production. Phe‑Ile‑Ala‑Trp‑Leu‑Val‑Lys‑Gly‑Arg‑X1‑X2(I). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111018963-A |
| priorityDate |
2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |