http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109718225-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-439 |
| filingDate | 2019-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109718225-B |
| titleOfInvention | Granisetron slow release microspheres and preparation method thereof |
| abstract | The invention relates to a preparation method of granisetron sustained-release microspheres, which comprises the following steps: dissolving granisetron and a degradable polymer containing a hydrophobic chain segment in an organic solvent to obtain a drug-containing polymer solution; adding the drug-containing polymer solution into an aqueous phase under the condition of stirring to form O/W type emulsion, and removing an organic solvent in the emulsion; wherein the water phase contains a stabilizer, and the proportion of the stabilizer to the water phase is 0.1-5% (w/v); and under the condition of stirring, adding the dispersion system obtained in the step (a) into water for solidification to obtain the granisetron slow-release microspheres. The granisetron sustained-release microspheres disclosed by the invention are appropriate in particle size, round in shape, high in encapsulation rate, good in drug loading rate and free of burst release phenomenon, and can effectively solve the problems of short release time and poor patient compliance. |
| priorityDate | 2019-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.