| abstract |
In some aspects, the invention provides methods for identifying sequence variants in nucleic acid samples. In some embodiments, the method includes identifying sequence differences between a sequencing read and a reference sequence, and which will be present in at least two different circular polynucleotides, such as two circular polynucleotides with different junctions Sequence differences were identified as sequence variants. In some aspects, the present invention provides compositions and systems useful in the methods. |