| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9de52bba13e16028dffa8775e3f3f28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-18 |
| filingDate |
2017-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeead0994ab28113679197e4fe7b31d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6281d35db8088e8126801aae15e4e9bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e80686fd3d808a385cecf29af844ef3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8faa87d0f84d64ff09042078c49b27a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43b4678926bdff8ddab697dac27f4a26 |
| publicationDate |
2019-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109706133-A |
| titleOfInvention |
A group of novel esterases and their applications |
| abstract |
The present invention relates to a group of novel esterases and applications thereof, in particular to a group of thermophilic esterases with stereoselectivity for ibuprofen drugs and applications thereof. The invention uses the esterified derivative of ibuprofen as the screening substrate, and uses the microfluidic two-color fluorescence screening system to carry out multiple rounds of directed evolution transformation of the thermophilic esterase, and obtains a group of esterases with significantly improved stereoselectivity. The invention also relates to the application of the esterase in the preparation of arylpropionic acid molecular derivatives represented by ibuprofen. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022168062-A1 |
| priorityDate |
2017-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |