http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109705042-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d7e2f8fb5650d7d3616661464b67771 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-34 |
| filingDate | 2017-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcfc8419b76663a7f43f3d18bd746076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1d821d96fc5581f9a3dfdedcae48b43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaa0434227632142cf2279d5c8f59a88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f5df8e58f9953e3715719616ba34e02 |
| publicationDate | 2019-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109705042-A |
| titleOfInvention | A kind of preparation method of ambrisentan |
| abstract | The invention belongs to the field of drug synthesis, in particular to a preparation method of ambrisentan. In the preparation method, ambrisentan is prepared through benzyl protection reaction, condensation reaction, and benzyl protection group removal reaction. The benzyl-protected intermediate is directly put into the next-step reverse condensation reaction without post-processing; the debenzylation reaction adopts catalytic hydrogenation, which is green and environmentally friendly, and the reaction operation and post-processing are simple and convenient. The intermediate, the crude ambrisentan is obtained, and then the step of recrystallization with methanol/water mixed solvent is used to obtain high-purity ambrisentan. The overall route has few steps, high yield, short production cycle, simple operation, good reproducibility and mild conditions, and is suitable for industrial production. |
| priorityDate | 2017-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.