http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109704926-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2019-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109704926-B |
| titleOfInvention | Anticancer active molecular skeleton 1, 4-eneyne compound and preparation method and application thereof |
| abstract | The invention discloses an anticancer active molecular skeleton 1, 4-eneyne compound and a preparation method and application thereof. The preparation method comprises the steps of sequentially adding an allyl alcohol raw material, terminal alkyne, tetrakis (triphenylphosphine) palladium, bis (trifluoromethylsulfonyl) imide calcium and an additive into a reaction solvent, carrying out catalytic reaction for 12-48 hours at 100 ℃ in an argon atmosphere and under a stirring state, removing the reaction solvent in a reaction liquid, and purifying to obtain the 1, 4-eneyne compound with the anticancer active molecular skeleton. The 1, 4-eneyne compounds can be used for inhibiting human esophageal cancer cell. The amount of the palladium catalyst used in the method is 1 percent, the amount of the calcium catalyst used is 5 percent, and the dosage is very small but can achieve the expected effect; the substrate of the method has wide application range, for example, allyl alcohol can be various substituted phenyl, heterocycle and alkyl; the method is suitable for different types of allyl alcohol, and can synthesize the 1, 4-eneyne compound in a 10g scale; the 1, 4-eneyne compound has better anticancer activity. |
| priorityDate | 2019-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.