http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109701034-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2019-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109701034-B |
| titleOfInvention | CAGW polypeptide and TAT-NLS polypeptide modified gene-loaded compound and preparation method and application thereof |
| abstract | The invention provides a CAGW polypeptide and TAT-NLS polypeptide modified gene-loaded compound and a preparation method and application thereof, wherein the preparation method comprises the following steps: preparing polyethylene glycol-poly (lactide-co-ethylene-propylene-lactide) copolymer mPEG-b-PLGA; preparing poly (lactide-co-glycolide) -g-polyethyleneimine copolymer PLGA-g-PEI; PLGA-g-PEI-g-CAGW copolymer is prepared by taking PLGA-g-PEI as a raw material; PLGA-g-PEI-g-CAGW and mPEG-b-PLGA are self-assembled to prepare a targeting copolymer micelle; and adding pDNA and TAT-NLS into the targeting copolymer micelle to prepare the gene-loaded compound. The gene-carrying compound prepared by the invention has specific selectivity on cells, good penetrating ability and nuclear entering ability and high transfection efficiency. |
| priorityDate | 2019-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.