http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109701024-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 |
| filingDate | 2019-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109701024-B |
| titleOfInvention | New application of BK channel opener |
| abstract | The invention belongs to the field of biology, and particularly relates to a new application of a BK channel opener. The BK channel opener is selected from one or a combination of NS1619 and BMS 191011. The experimental methods of biochemical index detection, in vitro cell research, western blot, data analysis and the like after the BK channel openers NS1619 and BMS191011 are given to an animal model, show that the BK channel openers NS1619 and BMS191011 have the effects of inhibiting renal fibrosis, including the effects of inhibiting ECM accumulation, inhibiting the generation of renal fibrosis markers and inhibiting the effects of TGF/Smad signal pathways. The invention provides a theoretical basis for a mechanism of inhibiting the pharmacological actions such as renal fibrosis and the like, also lays a test basis for preparing a medicament for treating chronic renal diseases by using a BK channel opener, and has important significance. |
| priorityDate | 2019-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 254.