http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109694311-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-835 |
| filingDate | 2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109694311-B |
| titleOfInvention | Method for synthesizing isoliquiritigenin |
| abstract | The invention discloses a method for synthesizing isoliquiritigenin, which takes paeonol and p-hydroxybenzaldehyde as raw materials, directly synthesizes 4 '-methoxy-2', 4-dihydroxy chalcone by a claisen-Schmidt condensation reaction under the action of an alkaline catalyst, breaks off ether bonds in molecules under the action of hydrobromic acid, converts the ether bonds into 2 ', 4, 4' -trihydroxy chalcone which is the isoliquiritigenin, and obtains the isoliquiritigenin with higher purity after recrystallization. The charge ratio of paeonol to p-hydroxybenzaldehyde is as follows: paeonol (mol): p-hydroxybenzaldehyde (mol): 1. The synthesis of the isoliquiritigenin is carried out at normal temperature, the synthesis steps are few, the reaction time is short, the complex separation is not needed, the continuous operation can be carried out, the conversion rate of the raw materials is high, the total yield can reach 85%, and the product purity is over 96%. The synthesis process is green and environment-friendly, the raw material paeonol is cheap and easy to obtain, and the production cost of the product is low. |
| priorityDate | 2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.