abstract |
Fusion proteins comprising IL2 and IL2Rβ (eg CIRB), comprising IL2, IL2Rβ and IL21R (eg CIRB21), and/or comprising IL2, IL2Rβ, and CD28 (eg CIRB28); natural killer (NK) cells expressing these fusion proteins And methods of using these natural killer cells, for example, to treat subjects suffering from cancer; and regulatory T cells (T-regs) expressing fusion proteins comprising IL2, L2Rβ, and CD28, and using these regulatory T cells, for example, to treat patients with cancer. Methods for subjects with autoimmune disease or GVHD. |