| abstract |
The present invention discloses compounds of formulae (I) to (VIII) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein R 3 is substituted with R 3a and O to 2 R 3b tricyclic heteroaryl; and R 1 , R 2 , R 3a , R 3b , R 4 and n are defined in this application. The present invention also discloses methods of using these compounds as PAR4 inhibitors and pharmaceutical compositions comprising these compounds. These compounds are useful for inhibiting or preventing platelet aggregation, and for treating thromboembolic disorders or for the primary prevention of thromboembolic disorders. |